Endocrine Abstracts

The aim: Of this study was to investigate the association between two common CTLA-4 gene SNPs (49A/G in exon 1 and CT60 A/G in 3’UTR) and Graves’ disease outcome in Lithuanian population.Methods: This case-control study was performed in the Hospital of Lithuanian University of Health Sciences. Graves’ disease patients (n=105) were divided into remission and failed treatment groups according to the final outcome of the disease. The...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer of all cases of thyroid cancer. Fine-needle biopsy by ultrasonography is still the main diagnostic method of PTC, but there is a technical limitation. That’s why, a minimally invasive diagnostic test that can accurately diagnose the onset of the disease is the subject of research.Our objective: We aimed to explore the concentration levels of ...

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid cancer type. It carries a good prognosis. However, approximately ten percent of cases may present with metastatic disease at initial presentation. Fine needle aspiration biopsy cytology is still the gold standard for diagnosing PTC, but there is a technical limitation. That’s why minimally invasive diagnostic test is the subject of research in nowadays.Our objective: We aimed...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. For the majority of patients with PTC, the prognosis is very good; however, up to 20% of patients suffer disease recurrence. Currently, the risk stratification for PTC recurrence is based on clinicopathological features which have limited prognostic value. Identification of molecular biomarkers of PTC recurrence such as protooncogene BRAF and miRNAs may help to improve risk-stratifie...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer, accounting for about 80% of all cases of thyroid cancer. 20 – year survival rate is about 90%. However, PTC can be aggressive – up to 30% of the patients have local renewal or systemic spread.Our objective was to evaluated the clinicopathological factors of recurrence in completely resected PTC patients.Methods: A r...

Introduction: Despite low mortality rates of patients with papillary thyroid carcinoma (PTC), disease progression in PTC occurs in up to 20% of patients. Currently, recurrence risk stratification is accomplished by using clinicopathologic factors, despite their limited prognostic value. Some data suggest that patient age at disease onset and primary tumor size may predict the risk of disease progression. Identification of possible associations of traditional clinicopathologica...

Introduction: The sensitivity and specificity of biomarkers which have been used in clinical practice for diagnosis of papillary thyroid carcinoma (PTC) are low. It is essential to develop novel diagnostic biomarkers for PTC.Objective: We aimed to explore the expression levels of miR-222, – 146b, –181b in PTC tissue and plasma samples and to compare with benign thyroid nodules (BTN).Methods: We collected plasma samples ...